Antioxidant activity of capsaicin on radiationinduced oxidation of murine hepatic mitochondrial membrane preparation ramachandran gangabhagirathi,1 ravi joshi,2 1bioorganic division, 2radiation and photochemistry division, bhabha atomic research center, trombay, mumbai, india abstract. Request pdf radiation induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often. Ionizing radiation is known to induce oxidative stress through generation of reactive oxygen species ros resulting in imbalance of the prooxidant and antioxidant activities ultimately resulting in cell death. We have studied the effect of ferrous ions on radiation induced lipid peroxidation. Amelioration of ionizing radiation induced lipid peroxidation. Lipid peroxidation is shown to have importance in understanding the modifications of radiation effects. Pdf inhibition of radiationinduced lipid peroxidation. These results suggest that ferroptosis and lipid peroxidation contribute to radiationinduced cell death in ht1080 cells, and that this ferroptotic cell death can be enhanced by the addition of otherwise sublethal concentrations of ike or rsl3. Curcumin was incorporated into microsomes during ultracentrifugation. Capsaicin is the major capsaicinoid in chili peppers and is widely used as a spice. Modulation of radiation induced lipid peroxidation by phospholipase. Radiationinduced lipid peroxidation and membrane permeability. Although radiation is widely used to treat cancers, resistance mechanisms often develop and involve activation of dna repair and inhibition of apoptosis. Pdf amelioration of ionizing radiation induced lipid peroxidation in.
Calmodulin antagonists also decreased the cytochrome p450 content of microsomes. Inhibition of radiationinduced lipid peroxidation by. Antioxidant activity of capsaicin on radiationinduced. Additional methods and supplemental figures and tables pdf. Lipid peroxidation was found to increase with increase in concentrations of ferrous ions fig. Inhibition of radiation induced lipid peroxidation by tetrahydrocurcumin. Methylseleninic acid induces lipid peroxidation and radiation. Radiationinduced lipid peroxidation triggers ferroptosis. Ionizing radiationinduced metabolic oxidative stress and. Pdf scoparone inhibits ultraviolet radiationinduced lipid. Inhibition of radiationinduced lipid peroxidation by curcumin in n20 saturated rat liver microsomes. Radiationinduced peroxidation and fragmentation of lipids. Therefore, compounds that sensitize cancer cells to radiation via alternative cell death pathways are valuable.
Efforts are made to show similarities between radiolytic and. Protective effect of moringa oleifera leaf extract mole against radiationinduced lipid peroxidation has been investigated. Vitamin e and vitamin c completely protected against uvb radiation induced lipid peroxidation p induced a vitamin e consumption of up to 100% in the stratum corneum and viable epidermis, and a vitamin c consumption of only 21% in the stratum corneum. We report here that ferroptosis, a form of nonapoptotic cell death driven by lipid peroxidation, is partly responsible for. When the microsomes are irradiated in the presence of n20, the resulting lipid peroxidation is predominantly due to hydroxyl radicals. Topical antioxidant vitamins c and e prevent uvbradiation. Pdf protective effect of moringa oleifera leaf extract mole against radiationinduced lipid peroxidation has been investigated. Ionizing radiation track structure and the nature of induced biological effects ionizing radiation is classified as either electromagnetic or particulate.
Radiationinduced lipid peroxidation triggers ferroptosis and synergizes. Ionizing radiation is classified as either electromagnetic or particulate. Radiationinduced lipid peroxidation triggers ferroptosis and. Radiation induced peroxidation and fragmentation of lipids in a model membrane. Request pdf radiationinduced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers although radiation is widely used to treat cancers, resistance mechanisms often.
Pdf antioxidant capabilities of scoparone, the component of artemisia scoparia and other medicinal plants, against lipid peroxidation induced by. Inhibition of radiationinduced lipid peroxidation by tetrahydrocurcumin. Vitamin e and vitamin c completely protected against uvbradiationinduced lipid peroxidation p pdf 51 k pdf plus 97 k citing articles. The ability of curcumin, a natural antioxidant from turmeric, to inhibit radiationinduced lipid peroxidation in rat liver microsomes was examined. Pdf protective effect of moringa oleifera leaf extract mole against radiation induced lipid peroxidation has been investigated. Radiation induced lipid peroxidation in liposomes sciencedirect. Effects of calmodulin antagonists on radiationinduced. Lipid peroxidation after ionizing irradiation leads to apoptosis and. Pdf influence of ferulic acid on gammaradiation induced. We report here that ferroptosis, a form of nonapoptotic cell death driven by lipid peroxidation, is partly responsible for radiationinduced cancer cell death. The antioxidant has significant time and concentrationdependent inhibitory effect on lipid peroxidation induced by rradiation. The present study evaluated the hepatoprotective effect of aqueous ethanolic moringa oleifera leaf extract mole against radiationinduced oxidative stress, which is assessed in terms of inflammation and lipid peroxidation. Radiation induced peroxidative damage semantic scholar. Swiss albino mice were administered mole 300 mgkg of body weight for 15 consecutive days before exposing them to a single dose of 5 gy of 60 co.